Direct oral anticoagulants uptake and an oral anticoagulation paradox
نویسندگان
چکیده
منابع مشابه
Reimagining Anticoagulation Clinics in the Era of Direct Oral Anticoagulants.
Anticoagulation clinics were initially developed to provide safe and effective care for warfarin-treated patients with atrial fibrillation, venous thromboembolism, and mechanical valve replacement. Traditionally, these patients required ongoing laboratory monitoring and warfarin dose adjustment by expert providers. With the introduction of direct oral anticoagulants (dabigatran, rivaroxaban, ap...
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BACKGROUND Thrombotic disorders remain a leading cause of death in the Western World. For decades, vitamin K antagonists used in the prevention of this pathology, such as warfarin or sintrom, were the only oral agents available for long-term anticoagulation, in spite of their disadvantages. MATERIAL AND METHODS An electronic database search was carried out on MedLine and The Cochrane Library ...
متن کاملReversal of direct oral anticoagulants
Reversal agents for direct oral anticoagulants (DOACs), including factor X inhibitors and direct thrombin inhibitors, are a major concern in clinical practice. After DOACs were introduced and became widely used as an alternative for vitamin K antagonists in the management of venous thromboembolism and nonvalvular atrial fibrillation, the need for effective reversal agents has increased, particu...
متن کاملProlonged anticoagulation in VTE with direct oral anticoagulants: towards an individual analysis of net clinical benefit?
Venous thromboembolism (VTE) is a common, multifactorial and capricious disease. Its incidence is estimated at between 1 and 1.84 per 1000 person-years, half of cases consisting of isolated distal or proximal deep vein thrombosis (DVT), a quarter of isolated pulmonary embolism (PE) and the rest being PE associated with DVT [1, 2]. The direct severity depends on the mortality risk due to haemody...
متن کاملDirect oral anticoagulants and venous thromboembolism.
Venous thromboembolism (VTE), consisting of deep vein thrombosis and pulmonary embolism, is a major clinical concern associated with significant morbidity and mortality. The cornerstone of management of VTE is anticoagulation, and traditional anticoagulants include parenteral heparins and oral vitamin K antagonists. Recently, new oral anticoagulant drugs have been developed and licensed, includ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2020
ISSN: 0306-5251,1365-2125
DOI: 10.1111/bcp.14171